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Warfarin's much less powerful R-enantiomer is metabolized partly by CYP3A4 (and also CYP1A2 and CYP2C19). Observe INR extra regularly if coadministered with inhibitors of these isoenzymes and alter warfarin dose if essential.Coadministration of encorafenib with sensitive CYP3A4 substrates may well cause amplified toxicity or lowered efficacy of tho